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Although NGF infusion in the brain showed slight cognitive improvements in AD patients, long-term administration of NGF through ICV was associated with serious side effects, such as hyper-innervation of cerebral blood vessels [47], hypophagia [48] and neuropathic pain [46]

Notably, Brusatol, a natural NRF2 inhibitor, enhances the binding of KEAP1 to NRF2, promotes NRF2 ubiquitination, and accelerates its proteasomal degradation, thereby suppressing NRF2-driven antioxidant function and sensitizing cancer cells to oxidative stress

This is particularly important if you have existing health conditions or specific dietary needs

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The dose starts small and is increased slowly over several weeks so the body can adjust and manage side effects such as nausea

Discard the solution if it becomes cloudy , discolored , or contains visible particulates